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Ticks are a bunch of tiny arthropods and their main source of food is the blood of animals which includes humans. Ticks live in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tall grasses, trees, leaf litter, shrubs and sometimes in your own backyard. Ticks cannot jump or fly onto their host's body.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nstead they burrow into the skin without detection and start drawing blood. Soft-bodied ticks usually have their fill after a f

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ew hours but their hard-bodied cousins may stay on the host's skin for up to 2 weeks.

Although it is very rare to contract dis

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ase from ticks, they have been known to transmit the following disease to man:

Babesiosis
Rocky mountain spott

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d fever

Lyme disease

Human Granulocytic Ehrlichiosis (HGE)

Human Monocytic Ehrlichiosis (HME)

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

olorado tick fever

Relapsing fever

Q fever

Tick paralysis

Tularemia

The type of dise

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

se contracted depends on the location, type of tick, duration of the tick's attachment to the host's skin and season of the yea

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

.

How To Get Rid Of Ticks Yourself

Sterilize the tick bite area with disinfectant.
Put on a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

pair of PVC gloves if possible and use a pair of forceps or tweezers to clamp the tick close to the skin of it's head. Be caref

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

l not to twist, yank or crush the tick.

Pull the tick straight out and apply a constant amount of pressure until the ti

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

k cuts loose.

Use a sterilized needle to extract the tick's head or any other body part that was broken off in the skin

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Apply some antibiotic ointment onto the bite wound and area around it.

Wash your hands thoroughly with disinf

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ctant soap like Dettol to kill any traces of germs on your hands and fingers.

If possible, insert the removed tick into

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

a container and bring it to a doctor for identification. When You Should Consult A Doctor

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

You cannot remove the tick or part of the tick from the skin.

You develop a fever, rash, headache, muscle pains, joint

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ains or flu-like symptoms 2 to 14 days after the tick bite.

You develop widespread rashes 2 to 14 days after the tick b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

te.

You develop redness, pus, swelling or yellow drainage from the tick bite wound 1 to 2 days after the tick bite.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

You develop a red-ring or a bull's eye rash around the tick bite wound 3 to 30 days after the tick bite.

You have

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ifficulty moving your legs.

You feel unwell and want to make sure your illness is unrelated to your tick bite.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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