E-Articles - Health and Fitness

What do you really know about your skin? Do you know how it ages, what affects its appearance? Do you know how to take care of it properly? Your skin is really a complex organ, just like any other organ in your body.

Being educated about h

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ow your skin functions is becoming extremely important for those who want to help combat the signs of aging. Our skin reacts to everything in our environment, both positive and negative, and is the largest functioning organ that our body ha

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

. Your skin covers approximately 18 square feet and weighs between 5 and 8 pounds. It is responsible for protection from the elements, temperature regulation, sensation, and secretion. To give you an idea, each square inch of skin contain

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

, 65 hairs, 95-100 glands, 78 yards of nerves, 20 yards of blood vessels, 650 sweat glands, 9,500,000 cells, 1,300 nerve endings, 19,500 sensory cells, 78 sensory apparatuses to record heat and 13 sensory apparatuses to record cold. It is a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

extremely complex organ.

The keys to aging are prevention and protection. There are two types of aging, intrinsic or inside, and actinic or outside. Essentially from the day we are born our skin begins to break down. Think of how smooth t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e skin of a baby is.

The aging process is a combination of a decrease of collagen and elastin production. This collagen and elastin is what helps to give our skin strength. We want to protect our skin from this decrease. Unfortunately this

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

starts to happen usually around the age of 20. Our skin thickness also begins to decrease; usually about 6% every ten years. It is this thin skin that decreases the skins ability to retain moisture. The real key to aging is that the sun

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

auses approximately 90% of all the visual signs of aging.

Intrinsic aging is really something that is unavoidable. This is hereditary, its in our gene pool. Fortunately for those of you concerned about aging, this only accounts for about 1

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

% of the aging process. Actinic aging is avoidable. As I have already said, about 90% of the visible signs of aging are from the sun. These signs can include wrinkling, sagging, discoloration, pigmented spots and thin skin. These are things

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

that we can prevent with proper care.

Now to give you an aging timeline. Our first signs appear in our early twenties. Wrinkles start to appear around the eyes and the lips. They are caused by repetitive movements such as laughing. In our

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

thirties, the skin is less resilient. Our elastin production decreases, and gravity starts to take hold. In our forties the elasticity of our skin decreases even more. Our skin loses the ability to bounce back. How many of you have woken up

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

with lines from your pillow etched into your face? You've probably noticed that they don't disappear very quickly anymore. Permanent wrinkles also show up. These are caused by frowning, squinting, and cigarette smoking. Collagen and elas

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

in continues to decrease into our fifties. The skin and muscles start to sag. Strangely, the tip of the nose also starts to droop.

When it comes to intrinsic aging, the things we can't do anything about, loss of bone mass is crucial. When

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ur bone mass decreases, our skin mass does not. Essentially the bones shrink away from the skin, making it appear stretched. Hence the sagging. But remember, intrinsic aging is only about 10% of the aging process.

What can you do? Research

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

your skin care. Make sure that you are choosing a skin care line that will give you great visible results. Make sure that the skin care you are using is good quality. You want skin care that will help your skin stay moisturized and hydrated

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

There are a few key things to look for when purchasing skin care. Make sure that it is PH correct. Our skin naturally has an acidity of 5.5. When we use a product that is not correct, we are actually damaging the first layer on our skin

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

. Make sure that it is dermatologist tested. This is not the same as "approved" or "recommended". This would simply mean that a company has dropped samples off at a dermatologists office. If someone there is handing them out to clients, a c

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

mpany can say approved.

Finally, perhaps the most important thing to look for is an absence of mineral oil. Mineral oil is refined from crude oil. You might know it as baby oil. Mineral oil definitely has it's place if you need to create a

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

barrier between your skin and something else. Unfortunately, when used on the skin it is like wrapping your skin in plastic wrap. It is not letting your skin breathe, release toxins, or letting it sweat. It also means that your skin cannot

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

bsorb anything from the environment that it might need to. The truly tricky thing about mineral oil is that it's not always called mineral oil.

Remember our skin is the largest functioning organ that we possess. We need to take care of it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Astragalus root (Astragalus membranaceous) is derived from a perennial plant that grows in northern China and Mongolia. In China, this herb is considered one of the best for the immune system.

Usually when we consider the practical benefits of something we are looking for immediate results. In one sense meditation does not give us anything tangible on an outer plane. However meditation can be of immense benefit in both our inner life and also in our outer life.

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