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There are many myths about oily skin. You must know all the scientific facts about oily skin so th

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

at-

You remove excess oil, You maintain optimum surface oils to protect your skin from bacteria.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

The facts that you should know about oily skin are-

Oily skin is a genetic problem. You inherit

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the tendency to have oily skin. Sometimes hormones also play a role.

Oily skin caused by excess s

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

bum produced by sebaceous glands. This problem can be because of heredity or hormonal changes.

Re

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

oving oil from top of the skin does not increase oil production. You can use any product safely to

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

remove oils. Removing oils from the skin surface has no effect on oil production. Oil production

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

oes not increase.

Facial papers are safe to use. Many people believe that face oil blotting paper

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s reduce sebum production. But that is not the truth. The papers only absorb the surface oils.

Pe

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ple with oily skin develop wrinkles later than those with dry skin.

Oil should not be removed tot

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

lly from the skin. Oil with sweat makes the acid mantle, which creates a barrier for the bacteria.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Over washing can leave the skin free to be attacked by bacteria. Oil protects the skin by forming

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

acid mantle with sweat.

Isotretinoin(brand name- Accutane) is not a cure for oily skin. Isotretin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

oin does not reduce oil production substantially. Oil may return after stopping the use of Isotret

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

noin

Topical Retinoids can reduce oily skin problem substantially.

Glycolic and salicylic acid-

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

HA and BHA do not reduce oil production, but peel off the dead skin layer and remove the oils.

Th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

is article is only for informative purposes. This article is not intended to be a medical advise a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

d it is not a substitute for professional medical advice. Please consult your doctor for your medi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

cal concerns. Please follow any tip given in this article only after consulting your doctor. The a

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

thor is not liable for any outcome or damage resulting from information obtained from this article

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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