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For right skin care, it is important that we know about common skin problems that may hamper us. Irritant Contact Dermatitis is one such problem

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

that may waste all our efforts in skin care. Know more about Irritant Contact Dermatitis and skin care.

Any material that irritates your skin an

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

creates redness, itching, blisters, etc. is said to cause irritant contact dermatitis. Strong chemicals are not the only causes of irritant cont

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

act dermatitis. Many people develop it after touching many innocent looking materials. It all depends upon the length of contact, the temperature

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

your skin reaction, your skin type, etc. If your skin is very dry, you will get this condition faster. For correct skin care it is important tha

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

t you keep away from irritants.

Skin care and various dermatitis-

Irritant contact dermatitis is different than allergic contact dermatitis. In

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

allergic contact dermatitis, a material to which you are allergic causes the inflammation. In irritant contact dermatitis, the material irritates

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

your skin and hurts you before your skin repairs itself, thus causing the dermatitis. Irritant contact dermatitis is normally confined to the si

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e of contact. It is unlike allergic contact dermatitis, which may spread to a wider area. But many times, it becomes difficult to differentiate b

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

etween the two types of dermatitis.

Examples of common irritant contact dermatitis that create problem in skin care may include:

1) Housewives

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

czema, which is caused by daily contact with water, detergents and other household cleaning materials,

2) Dermatitis forming under rings wore on

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

fingers, because of accumulation of the irritant such as soap below the rings,

3) Cosmetics that may cause irritation, etc.

Common irritants ma

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

y include even water. Some people get dermatitis if they are in contact with water for a long time. Other common irritants are solvents, salts, a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

kalis, acids, detergents, etc. These irritants react with the skin cells and destroy them. They dissolve the skin oil, penetrate the skin and dam

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

age it. In extreme cases, the wound may be a big one. Most of the acids and alkalis cause burns, so be careful when you use them.

For proper ski

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

care, if you can find out about the irritant, which causes dermatitis, keep away from it. In case of sudden contact with strong irritants such a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s acids or alkalis, flush the area with copious amount of water and see a doctor as soon as possible. This kind of dermatitis is commonly treated

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

using topical antibiotics or steroids.

This article is only for informative purposes. This article is not intended to be a medical advise and it

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is not a substitute for professional medical advice. Please consult your doctor for your medical concerns. Please follow any tip given in this a

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ticle only after consulting your doctor. The author is not liable for any outcome or damage resulting from information obtained from this article

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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