E-Articles - Health and Fitness

Stretch marks can appear when there is a sudden weight gain, which is most commonly seen as a result

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of pregnancy, when there is a rapid stretching of the skin. Puberty is another time when stretch mark

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s can make an appearance, with males as well as females, when there is a sudden growth spurt in areas

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

such as the breasts, buttocks, hips and thighs.

Stretch marks occur when underlying tissue grows fa

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ter than the skin layers covering it, which causes small tears in the skin’s surface. Scar tissue for

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ms in these tears, creating stretch marks. They appear as streaks of red thinned skin that fades to t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

he white scar-like streaks over time. Stretch marks may also appear depressed or indented from the su

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rounding skin and will have a different texture.

Since stretch marks are basically scars, you cannot

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

realistically expect to eliminate them completely once they happen. Preventing stretch marks from ha

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ppening then would be essential. With that in mind, there natural ways to protect your skin, increase

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the elasticity and stimulate regeneration of new skin cells.

Vitamin E is one of the key ingredients

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

in promoting the production of new skin cells, and is a powerful antioxidant found naturally in plan

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ts and nuts like almonds, kiwi, and mangos. Clinical studies have shown such benefits as reduction in

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

scarring and the reduction of stretch marks. Vitamin E penetrates deeply into the skin to stimulate

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

he growth of new cells, and as a result, the stretch marks become thinner and fade over continuing tr

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eatments.

Many products on the market make wild claims to completely remove stretch marks, when that

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

just is not realistic. It is very difficult to remove existing stretch marks completely, especially

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

f you have never used anything to prevent them or treat them when they were new. Taking preventative

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

measures can help to diminish the appearance of stretch marks. Keep in mind though, that everyone’s s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

kin reacts differently and it is impossible to guarantee that stretch marks will disappear completely

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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