E-Articles - Health and Fitness

Much has been documented about the health benefits of consuming the antioxidant, Pycnogenol, as a means of deterring premature skin aging. For

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

one reason or another, the benefits of its topical application has received very little publicity, which is unfortunate, as it is far superior t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

o other, more common antioxidants found in anti-aging skin care products.

Pycnogenol is the registered trademark for the unique extract obtaine

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

d from the bark of French maritime pine trees. Extensive research has shown that it is a powerful antioxidant proven to have a significant effe

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ct on the skin when taken orally or applied topically. It is a super antioxidant in that it is 20 times more powerful than vitamin C and 50 tim

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s more powerful than vitamin E in fighting free radicals. It is dramatically more effective than lipoic acid and grapeseed extract. Studies ha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ve shown that it is 98% effective in fighting free radicals in skin tissue. In addition to its potent antioxidant activity, Pycnogenol also exh

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ibits anti-inflammatory properties, and supports microcirculation.

Wrinkles are a result of the breakdown of the fibers that support our skin,

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

namely, collagen and elastin. Pycnogenol works by binding to these fibers thereby inhibiting enzymes and free radicals from breaking them down.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

As a result, the development of wrinkles is deterred.

One of the most profound causes of premature skin damage is photo-aging, that caused by

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the sun. Pycnogenol protects the skin from accelerated aging that results from exposure to the sun’s ultra-violet rays. UV radiation damages c

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ollagen and elastin, creates free radical damage, and causes skin inflammation, . This extract contains substances that decrease the symptoms o

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

f chronic inflammation and protect the skin from sun damage, ozone, smog, pollution, and damaging free radicals. Consequently, it is an ideal i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ngredient for use in anti-aging and wrinkle creams. It is quickly absorbed by the skin and retained for as long as 72 hours while it neutralize

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s free radicals and prevents oxidation.

As is the case with any active anti-aging ingredient, the concentration of Pycnogenol in skin care prod

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cts must be sufficient enough to be effective. Token amounts that are there simply so manufacturers can claim its presence in the product just

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

won’t do it. Very few products contain this potent antioxidant because it is expensive. Although no specific levels for it in topical applicat

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ions have been determined, the most common amount used in skin serums and creams is typically 0.1 to 0.2%. The easiest way to determine if a pr

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

oduct contains enough of the antioxidant is to look at its color. The extract is brown in color. Any product that lists it as an ingredient an

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

d is not brown, has an insignificant concentration of it. Its name should also be listed near the top of the ingredients printed on the package

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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