E-Articles - Health and Fitness

Psoriasis is a skin condition which affects almost four million Americans each year. It's thought to be a problem caused by the body's own immune sys

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tem, and is not considered curable. The symptoms themselves are treatable though, and sometimes psoriasis can go into remission for many months at a

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ime.

With a healthy human body, new skin is generated about once each month. New skin cells develop deep below the surface of the skin, and slowly r

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ise as they become mature. The skin cells which are already on the surface will die off over that thirty day time frame, and by the time the new skin

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

cells reach the surface, the existing ones will be ready to shed.

With psoriasis however, the body generates skin cells at a much faster rate, and s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ends them to the surface in just three to five days instead of thirty. Since the surface skin cells are not yet fully died off, the new skin piles up

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

on the surface with existing skin. This creates thick scaley skin patches on the body which have silvery white flakes, which are called psoriasis pla

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ques.

These psoriasis plaques can be quite dry, itchy and red. Sometimes they'll become so dry they'll start cracking too. Psoriasis looks horrible

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nd can be terrible to live with, but it's not contagious. The body is over producing the skin cells because it feels something is wrong somewhere.

M

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

any doctors, researchers and medical specialists feel the body's own immune system is simply over reacting. There is some evidence that psoriasis is

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ereditary, and there is evidence which shows certain events in your life can trigger a psoriasis flare up too. Common events which can cause flare up

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s include periods of heavy stress or trauma, and severe illnesses such as strep throat.

Since there is no known cure for psoriasis, treatment revolv

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s around minimizing or reducing the symptoms of this skin condition. There are topical creams, ointments and salves which can be applied to the psori

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

asis plaques which can help them become softer and thinner for instance. There are also some which can help the itching and redness of psoriasis as w

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ll.

Most of the topical creams and ointments which are available by prescription only work by attempting to slow the skin's growth rate, or by slowi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ng your body's immune system.

Other psoriasis treatments can vary according to how severe the problem is. Sometimes psoriasis plaques can be reduced

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

by exposing them to sunlight, because the UV rays from the sun make the skin die off faster. You have to be careful using straight sunlight though, b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ecause if you burn an unaffected area of your skin, you could develop new psoriasis plaques in that area.

Medical treatments also use special direct

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d UV sunlight to help reduce the psoriasis plaques too. There are also both oral and injection drugs which are sometimes used for more severe cases o

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

f psoriasis. These drugs also often work by trying to suppress your body's immune system so that new skin growth is slowed down to a more normal rate

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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