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Glycolic acid, along with some other vitamin C peels are the most commonly used rejuvenation treatments for facial skin care. Glycolic facial peels and other members of the Alpha Hydroxy Acid (AHA) group

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

like lactic acid, malic acid, tartaric acid and citric acid peels are all chemically composed of carbon backbones. As naturally occurring chemicals, the AHA based treatments are one of the best categories

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

of natural skin care products available in the market today.

Obtained from sugar cane, glycolic acid facial peels is the most popular and commonly used facial skin procedure among the AHA treatme

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nts.

Effects of glycolic acid peel

With time and exposure to sunlight, there is a gradual slowing down of the rate at which old cells are replaced by newer cells. The surface of the skin w

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

th old cells sticking to it provides an aged appearance to the skin.

A treatment with glycolic acid peels loosens the inter-cellular substances that hold the surface skin cells to each other. When the in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tracellular cement is loosened, it allows the dead skin to peel off readily. Shedding of the old, sun-damaged surface of the skin helps to encourage new growth of the cells in the skin underneath. The new

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

growth of cells results in a fresher, healthier looking skin with more even color and texture.

Glycolic acid facial peels are generally known as superficial peels, because these peels penetrate only thr

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ugh the epidermis and papillary dermis to an average depth of 0.06mm. However, the repetitive use of glycolic acid facial peels has a profound effect on improving the texture of the skin.

The effect o

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

f glycolic acid facial peels on the deeper layers of the skin has also been observed with high concentration and long-term use. The deeper penetration of glycolic acid peels has been shown to help in

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

collagen and elastin regeneration helping the fine lines of aging to disappear.

On the whole, the effects of glycolic acid facial peels on the skin can be listed as follows:

• Smoothening of rou

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

h, dry skin
• Exfoliation of the dead cells
• Slowing down of the ageing process
• Improving the texture of sun-damaged skin
• Normalizing of oily, acne troubled skin
• Control

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of acne
• Glycolic acid peels can also be mixed with bleaching agents to correct pigment problems
• Glycolic acid peels can be used as pre-treatment before a TCA peel

Histological effects of g

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

lycolic acid treatment are manifested by reduction of stratum corneum thickness, increased epidermal thickness, more orderly differentiation of skin cells and dispersal of melanin within the basal layer.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Candidates for the glycolic acid peel

The biggest advantage of glycolic acid facial peels is that they can be safely used for all skin types. The treatment with glycolic acid peels is usef

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

l for the people with:

• Superficial wrinkles of the face, neck, upper chest and arms
• Uneven pigmentation
• Enlarged facial pores
• Superficial acne scars on the face
• Oily skin

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

> • Age spots
• Newly formed acne

Procedure for Treatment with Glycolic Acid Peel

Performing a glycolic acid peel just takes 15-20 minutes. Repeated peeling offers good anti-aging be

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nefits to the skin.

The strength of glycolic acid has been found to affect the results. Generally the strength of each peel ranges from 20-70%, depending on skin sensitivity and the state of the skin at

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

he start of the procedure.

After the face is cleansed thoroughly, the peel solution is applied for a few minutes or longer. The exact duration depends on the particular type of solution and its strength.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

The peel may sting mildly during the treatment.

The skin may be a little pink immediately after treatment. A little peeling may occur over the next few days. It can be disguised with moisturizer or norm

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

al make-up. Remember, protecting your skin from the sun is also important following these mild acid peels. Ask your doctor to recommend a sunblock with adequate UVA and UVB protection and use it every day

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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