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E-Articles - Contemporary Studies on Colloidal Silver as a Soap
Colloidal silver, a liquid suspension of the metal silver, is currently a hot topic in the world of medicine. While alternative medicine praises its use as an antibiotic, mainstream medicine considers it somewhat of a poison. But colloidal silver is neither a poison nor a panacea: It is a safe and proven topical an
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
tibiotic that may cautiously be used internally. Interest in colloidal silver has increased most recently, probably because illness causing organisms do not seem to build up a resistance to colloidal silver the way they do to pharmaceutical antibiotics. Antibiotics are becoming less effective as resistance to them
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
rows.
At the turn of the century, scientists had discovered that the body's most important fluids are colloidal in nature; suspended ultra-fine particles. Blood, for example, carries nutrition and oxygen to the body cells. This led to further studies on colloidal silver with some amazing findings.
However, it was
At the turn of the century, scientists had discovered that the body's most important fluids are colloidal in nature; suspended ultra-fine particles. Blood, for example, carries nutrition and oxygen to the body cells. This led to further studies on colloidal silver with some amazing findings.
However, it was
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
not until 1970’s when colloidal silver established its real identity. During this period, Dr. Robert O. Becker, MD, noted biomedical researcher from Syracuse University, and author of The Body Electric and Cross Currents, conducted several experiments with colloidal silver. Under his expert guidance, extensive rese
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
rch into the curative properties of silver has been conducted for many years at the Upstate Medical Center, Syracuse University. The experiments conclude that silver works on a wide range of bacteria, without any known side-effects or damage to the cells of the body. He recognized a correlation between low silver
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
evels and sickness. He said silver deficiency is responsible for the improper functioning of the immune system. Regarding the innate ability of metallic silver to control infection, Dr. Becker said: "all of the organisms that we tested were sensitive to the electrically generated silver ion, including some that wer
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
resistant to all known antibiotics. Colloidal silver stimulates bone-forming cells, cures the most common stubborn infections of all kinds of bacteria, and stimulates healing in the skin and other soft tissues." On the safety of silver, he said, "in no case were any undesirable side effects of the silver treatment
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
apparent.” He concluded with his statement “What we have actually done was rediscover the fact that silver kills bacteria, which had been known for centuries ... when antibiotics were discovered, clinical uses for silver as an antibiotic were discarded.”
The March 1978 issue of Science Digest, in an article, "Our
The March 1978 issue of Science Digest, in an article, "Our
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
Mightiest Germ Fighter," reported: "Thanks to eye-opening research, silver is emerging as a wonder of modern medicine. An antibiotic kills perhaps a half-dozen different disease organisms, but silver kills some 650. Resistant strains fail to develop. Moreover, silver is virtually non-toxic." The article ended with
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
quote by Dr. Harry Margraf, a biochemist and pioneering silver researcher who worked with the late Carl Moyer, M.D., chairman of Washington University's Department of Surgery in the 1970s: "Silver is the best all-around germ fighter we have."
Former teacher of physics and chemistry, Howard Mitchell of Virginia, r
Former teacher of physics and chemistry, Howard Mitchell of Virginia, r
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
cently conducted a series of experiments with colloidal silver. He found that colloidal silver has no effect on acidophilus, the "good bacteria" found in the stomach. Mitchell used concentrations forty times higher than what might be expected to destroy other forms of bacteria. It shows that even in large dosage
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
, the intestinal flora will flourish. In fact, there is speculation that the silver ions may be advantageous in stimulating a vigorous growth of beneficial bacteria, helping to boost the immune system. This is good news! Some people experience diarrhea when they ingest too much colloidal silver. No problem, they
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
cut back on the amount of colloidal silver, and the lactobacilli counts return to normal within 12 hours without any intervention.
An obscure but crucial discovery was made at the Biochemistry Unit of Upjohn Laboratories in 1991: "Among a number of metal ions tested, Zn2+ (zinc), Cn2+ (copper), and Ag1+ (silver
An obscure but crucial discovery was made at the Biochemistry Unit of Upjohn Laboratories in 1991: "Among a number of metal ions tested, Zn2+ (zinc), Cn2+ (copper), and Ag1+ (silver
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
were found to be the most effective inhibitors of renin and the HIV protease (data not shown). Further analysis revealed that inhibition of renin by Ag1+ (silver) is basically identical with that seen with Zn2+ (zinc), i.e., concompetitive, first order with respect to the metal." Biochemistry, September 10, 1991.
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
Further testing at Upjohn, including a clinical trial, revealed that zinc was toxic in effective dosages. This was the first report that silver is a highly effective protease inhibitor. Over the following years, this same discovery would be made several times. Tichy, a full time member of the administrative staff a
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
Brigham Young University's physical plant, said he had the material tested at two different labs; results showed the solution killed a variety of pathogens, including the HIV virus.
A year later, this same discovery was made at the University Medical Center in Geneva, Switzerland: "Metal-binding proteins are imp
A year later, this same discovery was made at the University Medical Center in Geneva, Switzerland: "Metal-binding proteins are imp
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
rtant components of retroviruses such as human immunodeficiency virus (HIV). Therefore, metals could be used as antiviral agents. Silver is a highly active bactericidal metal with little toxicity for humans. Silver has also been shown to be a potent inhibitor of HIV protease."
Three years later, Temple University
Three years later, Temple University
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
in Philadelphia, Pennsylvania, USA, made this same discovery apparently independently by Earl E. Henderson, Ph.D. Professor: "We tested the ability of biotic silver protein to inhibit human immunodeficiency virus type 1 (HIV-1) replication in the human T cell line, SupT 1, as measured by syncytia formation. We fou
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
d that pure silver protein inhibited HIV-1 replication in SupT 1 cells as measured by a reduction in the appearance syncytia in cell culture. There appeared to be little if any acute toxicity associated with the dose of biotic silver protein which inhibited HIV-1 replication...These results are very encouraging and
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
suggest additional experiments that could be done..."
A lot of research is still being conducted with colloidal silver and with it, colloidal silver is making inroads to our daily life. It is being used as a main ingredient for making soaps. With its germ fighting virtues, such soaps are quite popular among masses
A lot of research is still being conducted with colloidal silver and with it, colloidal silver is making inroads to our daily life. It is being used as a main ingredient for making soaps. With its germ fighting virtues, such soaps are quite popular among masses
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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