E-Articles - Health and Fitness

In order to slow down and possibly reverse skin aging, we first need to understand how the skin changes with aging and the factors that accelerate those changes. Two primary aging mechanisms exist - intrinsic o

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

r biological aging and extrinsic or external aging. Intrinsic aging is inevitable as it is part of the natural aging process. Our skin cells, just like our bodies, begin to slow down. Extrinsic aging is the c

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

umulative effect of many assaults on the skin throughout one’s lifetime that cause it to age prematurely.

INTRINSIC AGING

Although these changes are inevitable, there are measures that can be taken to slow the

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

process and possibly replace what nature has taken away.

The outer most layer of the skin, the epidermis, begins to thin. It receives less nutrients and the removal of waste products, including free radicals

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

declines.

Collagen, the framework which supports the skin, production slows leading to lines, wrinkles and sagging.

Elastin, the substance that allows our skin to “snap back” into place no longer has the sprin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

g it once did.

Dead skin cells do not shed as quickly and turnover of new skin cells decreases. Instead of being renewed every 2 or 3 weeks, aging skin takes 4 to 6 weeks to be replaced.

Decreased oil product

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ion causes skin to become dry.

Loss of underlying fat leads to hollow cheeks and eye sockets.

Bone loss causes the bones to shrink away from the skin and sagging develops.

EXTRINSIC AGING

Unlike intrinsic ag

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ing, extrinsic aging is much more manageable. There are numerous outside factors that accelerate the visible signs of aging. Avoiding them is the most cost effective anti-aging strategy. Unfortunately, for ma

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y of us, they have already done their damage.

Sun

Photoaging is that which is produced by exposure to the sun’s rays. Exposure to ultra-violet (UV) rays results in the formation of free radicals. Free radica

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ls are unstable atoms or molecules that are extremely reactive. In order to stabilize themselves, they attach to other “normal” molecules causing modification or damage to them. Aging is the cumulative effect

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of many free radical attacks over time. With repeated exposure to the sun, the skin loses its ability to repair itself and the damage accumulates. The collagen breaks down and its synthesis is impaired. The e

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

lastin weakens. The skin becomes loose, wrinkled and leathery. Freckles, age spots, spider veins, blotchiness and skin cancer have all been traced to sun exposure.

Repetitive Facial Expressions

Think about t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e number of facial expressions you have every day. Research studies have shown that individuals make approximately 15,000 facial movements per day. Each time the face moves for an expression, the skin is stret

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ched. When young, the skin snaps back into place, similar to a rubber band. As we age, it does not snap back and permanent expression lines form. These are seen as frown lines, smile lines, crow’s feet and li

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

p lines.

Gravity

The force of gravity constantly pulls on the body causing changes that become more pronounced as we age. It causes the eyelid to fall and jowls to form. The tip of the nose begins to droop,

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the ears elongate and the upper lip begins to disappear while the lower lip becomes more pronounced.

Sleeping Positions

Sleeping with your face pressed against a pillow night after night can cause “sleep lines

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

that, over the years, become etched in the skin and become wrinkles. Dermatologists are actually able to determine the side of the face you sleep on by looking at your wrinkles.

Smoking

Exposure to cigarette

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

smoke leads to the formation of free radicals and weakens the skin’s collagen and elastin fibers. It also constricts the blood vessels, depriving the skin of the oxygen and nutrients it needs to remain healthy

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

.

Chlorine

The chlorine in water does more than make it safe to drink - it ruins your skin. Chlorine is an oxidative agent designed to attack living organic matter which is why it kills bacteria in water supp

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lies. Unfortunately, the skin is also living organic matter which is vulnerable to the effects of chlorine.

Avoiding as many of the above external stressors as possible will make your skin look younger, longer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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