E-Articles - Health and Fitness

The average adult skin weighs 6 pounds and measures 20 square feet when stretched out. This, our largest organ, is often the most neglected when it comes to protecting it from its wo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rst enemy - the sun. It is vital that you routinely use a form of sun protection as part of your basic skin care routine to prevent skin cancer and retard skin aging. UVA and UVB ar

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the types of sun's rays that are known to cause skin damage. Consequently, when choosing sunscreens, it is important that it be "broad spectrum", meaning that it protects you from b

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

th UVA and UVB radiation. Active ingredients in sun protection products can be divided into chemical versus physical agents.

Chemical "sunscreens" work by absorbing the energy of UV

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

radiation before it affects your skin. Most are composed of several active ingredients because no single chemical ingredient absorbs the entire UV spectrum. Only a few chemicals pro

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ect against the UVA spectrum, one of which is avobenzone. Since these sunscreens are chemical in nature, they carry the potential of causing adverse skin reactions when used on a dai

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

y basis, particularly if you have sensitive skin. They must also be applied at least 30 minutes before sun exposure, allowing them adequate time for absorption, so that they may func

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

tion effectively.

Physical "sunblocks" reflect or scatter UV radiation before it reaches the skin. The two types of physical sunblocks currently available are zinc oxide and titaniu

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

dioxide. Both provide broad spectrum UVA and UVB protection and are gentle enough for everyday use because they are physical agents and not chemicals. As a result, they rarely caus

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

skin irritation.

Although incidental sun exposure, that which we obtain by simply being out and about, accounts for 80% of the total exposure we experience in a lifetime, only 40% o

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

adults use some form of sun protection regularly. An astonishing 25% of individuals never use it at all. Issues of time and product consistency are often reasons for foregoing thei

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

use.

One of the easiest ways to incorporate sun protection into you daily skin care regimen is to use mineral makeup. Mineral makeup is made from naturally occurring pigments from

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

he earth and is free from synthetic chemicals that can harm the skin. It contains titanium dioxide, which provides broad spectrum UVA/UVB, SPF 15, protection. It is quick and easy t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

use. Since it is a physical sunblock rather than a chemical sunscreen, it can be applied immediately before sun exposure. The 30 minute wait period that is associated with using ch

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

emical sunscreens does not apply. Mineral makeup is available as foundations, blushers, and bronzers making it more aesthetically appealing than the heavy and greasy sunscreens of th

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

past. It is virtually undetectable in look and feel on the skin, making it ideal for use by men and women, alike.

If you are not using some form of sun protection regularly because

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

you simply don't have the time, there is now a facial cleanser available that literally allows you to "wash on" your sunscreen when you cleanse your face in the morning. So if time i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

an issue for you, you might want to consider this option.

Of course, if you are planning a day at the beach or an activity that will require you to be in strong sunlight for a lengt

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

y period of time, I highly recommend that you use a broad spectrum product with an SPF of 30 or greater. Most of these products are chemical in nature and may aggravate some skin typ

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s. Consult your dermatologist or other skin care professional for advice on products that are effective yet gentle, particularly if you have sensitive skin or other skin conditions

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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E-Articles - Understanding Sunscreens - Protect Yourself from Skin Cancer and Premature Aging

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