E-Articles - Health and Fitness

We all know that the sun causes a lot of damage to the body. As well as the risk of skin cancer, there is also the risk of burning and premature ageing. If we do not protect oursel

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ves properly we really are putting our health at an unnecessary risk.

So just how much do you know about the sun and the dangers? Obviously we are warned all the time, but do you

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

understand why the suns rays? Do you know which one out of UVC, UVB or UVA is worse for you? Thought not!

The Difference between UVC, UVB and UVA Radiation

The sun gives off vari

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ous different levels of radiation and they are categorized into three main groups.

These are:

UVC

UVC does not bother the skin at all as it is all soaked up into the ozone layer

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

This type of radiation is also found in things such as germicidal lamps and mercury arc lamps.

UVB

This type of radiation does affect the skin and its main target is the epiderm

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

is, or the outer layers. This is the main radiation which causes sunburn and it is usually at its strongest between 10.00am and 2.00pm. This is generally when the sun is at its bri

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ghtest and in the summer months this type of radiation accounts for up to 70% of a person’s annual UVB dose. As strong as it is, it cannot travel through glass.

UVA

UVA radiation

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

is a main contributor to skin cancer. It used to be thought that it was actually only a minor problem for the skin, but studies have shown that it is in fact quite severe. This is

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

because it goes deeper into the skin than USB radiation and it often is more constant throughout the year. This type of radiation also cannot go through glass.

The Damage They Can

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

Cause

As well as skin cancer, the suns radiation can also cause problems with the eyes including cataracts and other eye damage. It can also affect the immune system and stop it

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

rom working properly.

Too much sun exposure can also cause problems with the texture of the skin. It can often become either thicker or thinner due to the radiation. Thicker skin

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

generally appears with wrinkles, especially at the back of the neck. Thinner skin tends to create fine lines and it bruises a lot easier too.

The blood vessels are also affected b

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

y the sun and the walls of the vessels often become thinner. This usually leads to bruising and sometimes the appearance of tiny blood vessels can occur on the face.

Bumps in the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

skin may also appear, especially moles. These do have to be kept an eye on though as they could become cancerous. Lesions and other bumps can also make an appearance and again they

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

need to be kept an eye on.

The Various Strengths of UV Radiation

The suns radiation is not always really strong. You can usually tell how high the levels are going to be on your

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

local weather forecast. They are mainly given out during the summer months so that you know which strength sunscreen to buy, however they do sometimes give them out in cooler month

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s too. The higher the radiations, the more chance of getting burnt you have, and the higher protection factor you will need.

Various things can affect the radiation levels and if

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

here is snow on the ground for example, a lot of radiation bounces off the snow and it can go straight into the body. The cloud cover makes a difference too, as does the height of

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the sun. If the sun is really high in the sky the UV levels will also be really high.

Overall various factors affect the UV levels and you should always check to see which protect

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ion factor strength you will need. The sun's radiation can really do our skin some damage so it is better to cover up than to grow old too quickly and develop various skin problems

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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