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Let's face it, once you've had Cystitis once, it's an experience that you are unlikely to forget in a hurry. The symptoms m

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ost seem to identify with are the constant urge to use the toilet; not too mention the horrendous burning sensation that comes with it. OUC

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

H! Makes you wince, just thinking about it!

For those of you who are lucky enough not to have experienced it, Cystitis is an infection

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

that occurs in the lining of the Urethra or the lining of the bladder.

According to the statistics most women will experience Cystitis anytime

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

from their early twenties right through to the Menopause.

The usual medical advice tends to be to drink plenty of water to help flush out your sys

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

em. You may have even heard that Cranberry Juice is good for Cystitis; well, not necessarily so, according to Dr Larrian Gillespie

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

- "If you have an infection, taking Cranberry Juice (contains Hyppuronic Acid) makes as much sense as putting out a fire with gasoline! Adding more

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

acid to the urine only serves to make the burning WORSE! However, that being said, Cranberry Juice is thought to be useful for PREVENTING<

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

strong> an infection.

So whilst Cranberry Juice may not be your best option for TREATING a bout of Cystitis; what is the alternative? I hear you sa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

y! I'll give you two words, Magnetic Therapy. This therapy involves the application of therapeutic Magnets directly above the site of pain or inj

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ry. There are no drugs and no needles.

Once the magnets have been applied (north side up), they generate a magnetic field which is strong enough to

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

penetrate through bones, tissues and cells. This results in increased circulation thus allowing more Oxygen and nutrients to be transported to the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

where it is needed most.

When the body is in a healthy state, there is a good supply of oxygen in the blood and the fluids will register as
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ong>alkaline. However, when the body is ill, i.e., in the case of an infection, the bodily fluids become acidic and the amount of oxyg

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

en becomes reduced.

Applying a Negative Magnetic Field will help to increase circulation, therefore increases the flow of oxygen;

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

as well as returning the bodily fluids from an acidic to an alkaline optimal state.

According to a study conducted by New Jersey

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Institute of Technology, a Negative Magnetic Field will significantly decrease the rate at which bacteria spreads. Therefore, demons

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

trating that Magnet Therapy can be effective at tackling infections.

As I bring this article to a close, I must point out that sometimes Cystitis c

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

n be accompanied by more serious symptoms such as fever, nausea, back/groin pain, vomiting and blood in the urine. Should you experience this, do no

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

t take any chances, go see a doctor, as this might indicate serious problems with your kidneys. In the meantime, know your options and stay well

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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