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"Moses holded out his stick, and it splitted up," says Jessica, age 6. "It was a miracle when Moses put the stick into the big sea," adds Hillary, 6.

Gee, I wonder if Teddy Ro

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

osevelt was thinking of Moses when he said, "Speak softly and carry a big stick; you will go far."

Indeed, Moses did go far, but it wasn't because he depended upon his big sti

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ck. Forty years before, he had relied on his own strength when he killed an Egyptian who was beating a fellow Jew. But now, when the Lord told him to lift up his rod and stretc

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

h out his hand over the Red Sea, he obeyed and trusted in the power of God. Read Exodus 14 for the full account.

"If you trust God, he will help you in sticky situations," say

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s Rachel, 11. Does this include wet situations as well? Sticky or wet, there are times in life when we face impossible circumstances.

"Trust in the Lord even when you are scar

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ed," says Shannon, 11. The Bible tells us the people of Israel were "very afraid" -- so much so that they harassed Moses and asked him if he'd brought them into the wilderness

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to die.

Moses told the Israelites to "stand still and watch the salvation of the Lord." Sometimes, the most difficult thing to do is nothing -- not passivity but active faith

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hat stands on tiptoes watching for what God is going to do.

"It means to me that no false god can overcome the true God," says Michael, 10. The big showdown with the gods of E

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

gypt started with another big stick. This one belonged to Aaron, the brother of Moses. He threw his rod down before Pharaoh, and it became a serpent. Although Egypt's magicians

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

imitated the miracle, they probably didn't count on their snakes being eaten by the snake God made from Aaron's rod.

I wonder if Aaron's motto became "Speak softly and carry

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a big stick that eats other big sticks."

The big stick came into play again as Aaron stretched forth his rod over the waters of Egypt and turned them into blood. The Egyptians

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

believed in the Nile River god Hapi. After Aaron stretched forth his rod over the Nile, Hapi became sad, and Pharaoh hardened his heart.

"The lesson (of the exodus) is if you

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

need the Lord's help, call upon him, and he will help you," says Amber, 11. Throughout the Bible, the people of God are known as those who call on the name of the Lord.

For t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

he prophets, Jesus and the New Testament apostles, the physical salvation of Israel at the Red Sea was a picture of spiritual salvation. Israel's prophets constantly appealed t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the exodus as the basis for calling the nation to obedience. The yearly Passover feast commemorated the salvation of Israel's first born. The angel of death passed over the ho

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

uses whose entrances were marked with lamb's blood.

John the Baptist called Jesus the Lamb of God who takes away the sin of the world. And at the last Passover meal when Jesus

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ate with his disciples, he used the bread and the wine of the Passover feast to symbolize a new covenant based on his sacrifice.

The wine, Jesus said, represented his blood,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

and the bread his body. He was the true Passover lamb to which all the previous sacrificial lambs had pointed. Those who have his blood over the doors of their lives will exper

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ience an exodus when death comes knocking.

Point to ponder: Jesus is the Passover Lamb of God and the exodus from death.

Scripture to remember: "For indeed, Christ, our Passo

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ver, was sacrificed for us" (I Corinthians 5:7).

Question to consider: Have you applied the blood of the Lamb to your life by trusting in Jesus alone as your exodus from death

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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